Archives: Projects

Gonzalez JA, Maduka Ogba O, Morehouse GF, Rosson N, Houk KN, Leach AG, Cheong PHY, Burke, MD, Lloyd-Jones GC. MIDA boronates are hydrolyzed fast and slow by two different mechanisms. Nat Chem. 2016;8:1067-1075.

Paper on experiments to probe the mechanism by which MIDA boronates hydrolyze to enable future synthetic efforts toward biologically- and medicinally-relevant molecules

Li J, Ballmer SG, Gillis EP, Fujii S, Schmidt MJ, Palazzolo AME, Lehmann JW, Morehouse GF, Burke MD. Synthesis of many different types of organic small molecules using one automated process. Science. 2015;347:1221-1226.

Publication on the development of an automated platform to enable biological and medicinal investigations into small molecule chemistry.

Morehouse GF. Mechanistic investigations into the sulfonamide metathesis and copper(I)-catalyzed nitrile oxide-alkyne cyclization reactions, the synthesis of chemogenetic and proteomic tools and ligands for novel imaging agents, and theoretical calculations on carbenes [master’s thesis], Boston: Northeastern University; 2009.

The research presented in fulfillment of my Master’s Degree at Northeastern University. Portions were completed at Merck Research Labs in Boston and Novartis Institutes of BioMedical Research in Cambridge, MA.